The stadium is used for different football events; in its first year, it was used for a live screening of the 2019 UEFA Champions League Final, select Under-23s games.
Tottenham Hotspur Stadium is the first and only stadium to be designed specifically for NFL games outside of North America. The first game at the stadium took place on October 6, 2019, when the Chicago Bears played against the Oakland Raiders. A record crowd of 60,463 watched the Raiders win a close game 24–21. The following week, the Tampa Bay Buccaneers hosted the Carolina Panthers on October 13.